ABSTRACT
Em amostra de lavado vesical de 76 pacientes com carcinoma de células transicionais de bexiga realizou-se pesquisa do antígeno carcinoembrionário (CEA) pelo método imunocitoquímico. Histologicamente, 10,5 por cento, 47,4 por cento, 32,9 por cento e 9,2 por cento dos tumores eram grau I, grau II, grau III e grau IV, respectivamente. O CEA estava presente em 69,7 por cento e ausente em 27,2 por cento das amostras. Observou-se presença de infiltraçäo muscular pelo tumor em 64,4 por cento dos pacientes e ausência em 31,6 por cento. Os autores concluíram que o estudo do CEA em amostra de lavado vesical näo contribuiu para a avaliaçäo do potencial de infiltraçäo do tumor em portadores de carcinoma da célula transicional de bexiga
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Carcinoembryonic Antigen/analysis , Carcinoma/diagnosis , Neoplasm Invasiveness/diagnosis , Urinary Bladder Neoplasms/diagnosis , Carcinoma/classification , Carcinoma/metabolism , Immunohistochemistry , Urinary Bladder Neoplasms/classification , Urinary Bladder Neoplasms/metabolismABSTRACT
Lesions involving the sympathetic (para-vertebral ganglia) and para-sympathetic ganglia of intestins (Auerbach plexus) and heart (right atrial ganglia) were comparatively analyzed in mice infected with either of three different strain types of Trypanosoma cruzi, during acute and chronic infection, in an attempt to understand the influence of parasite strain in causing autonomic nervous system pathology. Ganglionar involvement with neuronal destruction appeared to inflammation, which most of the times extended from neighboring adipose and cardiac, smooth and striated muscular tissues. Intraganglionic parasitism was exceptional. Inflammation involving peripheral nervous tissue exhibited a focal character and its variability in the several groups examined appeared unpredictable. Althought lesions were generally more severe with the Y strain, comparative qualitative study did not allow the conclusion, under the present experimental conditions, that one strain was more pathogenic to the autonomic nervous system than others. No special tropism of the parasites from any strain toward autonomic ganglia was disclosed.